Skip to content

Effects of quadratus lumborum block with bupivacaine liposome on analgesia and stress response after cesarean section with minimally invasive spinal anesthesia

Effects of quadratus lumborum block with bupivacaine liposome on analgesia and stress response after cesarean section with minimally invasive spinal anesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500111701
Enrollment
Unknown
Registered
2025-11-04
Start date
2025-11-15
Completion date
Unknown
Last updated
2025-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain after cesarean section

Interventions

LB Quadratus lumborum block Group (LB Group):After the cesarean section, ultrasound-guided bilateral LB-QLB was performed by an experienced anesthesiologist
Bupivacaine hydrochloride quadratus lumborum block group (Group B):After the cesarean section, bilateral B-QLB under ultrasound guidance is performed by an experienced anesthesiologist

Sponsors

Hefei Maternal and Child Health Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for cesarean section of the lower uterine segment under minimally invasive spinal anesthesia; 2. Term 37-41 gestational weeks; 3. Singleton pregnancy; 4. Aged 20-40years; 5. BMI 21.0-35.0 kg/m^2; 6. ASA grade II or III.

Exclusion criteria

Exclusion criteria: 1. Any related major cardiac or respiratory disease, hematological system disease or coagulation parameter disorder, pre-existing vital organ dysfunction (such as liver and kidney failure). 2. Contraindications of neuraxial anesthesia and nerve block. 3. Severe pregnancy complications (high-risk pregnancy such as severe preeclampsia, placental abruption and complete placenta previa). 4. Known fetal abnormalities. 5. History of chronic pain. 6. Patients with mental disorders or inability to understand NRS scores. 7. Patients allergic to opioid or liposomal bupivacaine. 8. Patients who refused to participate in the study.

Design outcomes

Primary

MeasureTime frame
The consumption of opioid drugs within 0-72 hours;

Secondary

MeasureTime frame
Area under the 0-72 hours pain numerical score curve (AUC);NRS score at rest;NRS scores during cough/activity;Patient comfort score (BCS);Mean arterial pressure;Heart rate;Rescue analgesia was required after operation;Time for getting out of bed and moving around;Length of stay;The time of the first postoperative intestinal exhaust;Satisfaction with postoperative analgesia;The incidence of complications;

Countries

China

Contacts

Public ContactLei Xie

Hefei Maternal and Child Health Hospital

xielei169@163.com+86 551 6216 0071

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026