postoperative nausea and vomiting
Conditions
Interventions
Combination therapy group:The combination therapy group received intravenous injection of 10mg Azasetron combined with 0.5 µ g/kg Dexmedetomidine (the drug was diluted to 20ml with 0.9% sodium and adm
During the operation, propofol 3-6 mg/kg was administered while inhaling 1% -2% sevoflurane to maintain anesthesia.
Control group:The control group received intravenous injection of 10mg Azasetron (administered via a micro infusion pump within 20 minutes), fentanyl 4-6ug/kg, and propofol 3mg/kg for anesthesia induc
Sponsors
Suzhou Ninth Hospital Affiliated to Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age18~65 years; 2. American Society of Anesthesiologists (ASA) physical status I-II; 3.Body mass index (BMI) between 18-30kg/m^2 4.Scheduled for laparoscopic surgery.
Exclusion criteria
Exclusion criteria: 1. Sinus lesion syndrome or severe bradycardia (heart rate<50 beats/min); 2. History of hypertension or cardiac dysfunction; 3.Atrioventricular block of grade II or ? and no pacemaker installed; 4.Left ventricular ejection fraction <40%; 5.History of coronary heart disease or myocardial infarction; 6. Liver or renal dysfunction (Child-Pugh class C or undergoing renal replacement therapy); 7.Parkinson's disease or Alzheimer's disease; 8.Epilepsy or status epilepticus; 9.Pregnancy or lactation; 10.History of chronic pain or preoperative use of sedatives or analgesics; 11.Allergies to medications in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nausea;Vomiting;Visual analogue scale for pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Blood pressure;Dosage of analgesics for rescue;Dosage for rescue antiemetics;Length of hospital stay;Intraoperative opioid consumption; | — |
Countries
China
Contacts
Public ContactChao Zhang
Suzhou Ninth Hospital Affiliated to Soochow University
Outcome results
None listed