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Study on the Optimization of Flow Rate in PCV-VG Ventilation Mode for Improving Oxygenation in Obese Patients Under General Anesthesia

Study on the Optimization of Flow Rate in PCV-VG Ventilation Mode for Improving Oxygenation in Obese Patients Under General Anesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500111694
Enrollment
Unknown
Registered
2025-11-04
Start date
2025-11-07
Completion date
Unknown
Last updated
2025-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Interventions

Experimental Group (PCV-VG + Inspiratory-Expiratory Ratio Adjustment):Adjust the inhalation time
PCV-VG + Fixed Inspiratory-Expiratory Ratio:The inspiratory-expiratory ratio is fixed at 1:2

Sponsors

The First People's Hospital of Shuangliu District, Chengdu City
Lead Sponsor

Eligibility

Sex/Gender
All
Age
19 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1.Aged 19-60 years old, with American Society of Anesthesiologists (ASA) Physical Status Classification I-II; 2. Body Mass Index (BMI) ranging from 28.0 kg/m^2 to less than 37.5 kg/m^2; 3. Duration of mechanical ventilation >= 30 minutes; 4. Voluntarily agree to participate in this study, have signed the informed consent form, and are not participating in other studies; 5. No cognitive impairment; 6. No history of mental illnesses (such as depression, schizophrenia) or substance abuse.

Exclusion criteria

Exclusion criteria: 1.Body Mass Index (BMI) >= 37.5 kg/m^2; 2. Peripheral Oxygen Saturation (SpO2) < 94% on room air; 3. History of gastroesophageal reflux disease (GERD), chronic obstructive pulmonary disease (COPD), asthma, heart failure, ischemic cardiomyopathy, or smoking; 4. Patients who participated in other trials before being enrolled in this study; 5. Patients with admission and discharge within 24 hours; 6. Patients who are directly transferred to the Intensive Care Unit (ICU) after surgery and unable to cooperate with postoperative follow-up; 7. Patients with visual, auditory, or communication impairments; 8. Patients with shock, multiple organ failure, hypoxic-ischemic encephalopathy, pneumothorax, pregnancy, organ transplant recipients, etc.; patients undergoing thoracic surgery; 9. Patients with chronic obstructive pulmonary disease (COPD) or asthma;

Design outcomes

Primary

MeasureTime frame
Improvement Rate of Oxygenation Index;

Secondary

MeasureTime frame
The incidence of postoperative pulmonary complications;Incidence of Pulmonary Complications Within 72 Hours After Surgery;Respiratory mechanics indicators;Percentage of Central Ventilation Zone (CoV) Area;tidal impedance variation,TIV;

Countries

China

Contacts

Public ContactHu Yue

The First People's Hospital of Shuangliu District, Chengdu City

467667920@qq.com+86 182 2764 8792

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026