Focal injury of articular cartilage
Conditions
Interventions
Cartilage Injury Repair Group:Autologous cartilage-derived collagen membrane-wrapped cartilage fragment implantation
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-65 years old, gender not limited; 2.BMI index < 30; 3. Single or multiple articular cartilage defects, with a defect area of 1-3 cm^2, but without obvious bone defects; 4. No severe joint deformity (deformity Angle < 5°); 5. No systemic inflammatory diseases such as active arthritis and rheumatoid arthritis; 6. Preoperative MRI/PET-CT was used to rule out malignant lesions and severe bone lesions; 7. Be able to cooperate with postoperative rehabilitation and follow-up assessment, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Cell contamination or substandard quality was found during the in vitro membrane preparation process; 2. Combined with severe osteoporosis, diabetes, systemic connective tissue disease or immune deficiency; 3. Preoperative infection or recent use of immunosuppressants; 4. Pregnant or lactating women; 5. Previous history of ipsilateral joint replacement or major joint surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score;IKDC score;Lysholm score;MRI (T2 Mapping) examination;MOCART score; | — |
Countries
China
Contacts
Public ContactJiang Dong
Peking University Third Hospital
Outcome results
None listed