Pregnancy and pregnancy-related disorders (encompassing hypertensive disorders of pregnancy, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, gestational anemia, etc.) and offspring developmental impairments (including but not limited to fetal growth restriction, congenital heart disease, neurodevelopmental disorders, and growth faltering, etc.).
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1.Pregnant women in the early stage of pregnancy (<=13+6 weeks) who are 20 years old or older; 2. There are no plans for long-term residence or relocation in a different place from pregnancy to delivery. 3. No bad habits such as smoking, excessive drinking or drug abuse;
Exclusion criteria
Exclusion criteria: 1.Multiple pregnancies; 2. Combined with severe liver and kidney diseases, cancer and other underlying diseases; 3. Unable to cooperate in completing standardized data surveys and biological sample collection;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Outcome Measures; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gut Microbiome Analysis;Key Nutritional Metabolic Indicators;Lifestyle and psychological stress levels;Internal exposure levels of pollutants; | — |
Countries
China
Contacts
Ningbo First Hospital