Septic shock
Conditions
Interventions
fluid-responsive group vs. fluid-unresponsive group:volume expansion
Sponsors
Ningbo No.2 Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic criteria for septic shock according to the Third International Consensus Definitions for Sepsis and Septic Shock. 2. Aged >= 18 years; 3. Invasive mechanical ventilation without spontaneous breathing effort; 4. The attending physician decided to perform a fluid challenge test based on whether the patient had circulatory hypotension or tissue hypoperfusion. 5. Informed consent was obtained and the informed consent form was signed by the patient or their family members.
Exclusion criteria
Exclusion criteria: 1.Expected to die within 24 hours; 2.Aortic valve disease or aortic valve replacement surgery; 3.Poor ultrasound imaging or intolerance to echocardiography examination; 4.Cardiac assist devices such as extracorporeal membrane oxygenation, aortic balloon counterpulsation, or pacemaker support; 5.No central venous catheter or invasive arterial pressure monitoring; 6.At the time of diagnosis of septic shock, atrial fibrillation was occurring; 7.There is a contraindication to volume expansion;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac output variation (?CO); | — |
Secondary
| Measure | Time frame |
|---|---|
| left ventricular-arterial coupling (Effective arterial elastance / ventricular end-systolic elastance, Ea/Ees);Variation in the Ea/Ees ratio (?Ea/Ee);Hemodynamic parameters; | — |
Countries
China
Contacts
Public ContactZhou Xiaoyang
Ningbo No.2 Hospital
Outcome results
None listed