Intestinal Ischemia reperfusion injury
Conditions
Sponsors
The Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: >=18 years and 2 hours), ASA classification I-III; 3. Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of intestinal diseases (such as inflammatory bowel disease, intestinal obstruction, intestinal ischemia, intestinal tumors, etc.); 2. History of severe liver or kidney dysfunction (ALT or AST > 3 times the upper limit of normal, serum creatinine > 2 times the upper limit of normal); 3. History of metabolic diseases (such as diabetic ketoacidosis, severe diabetes, etc.); 4. History of autoimmune diseases; 5. Pregnant or breastfeeding women; 6. Use of probiotics or antibiotics within the past month; 7. Undergoing chemotherapy or radiotherapy within the past 3 months; 8. History of malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| H3 Lysine 9 Lactylation, H3K9la;Histone H3;Diamine oxidase;D-lactate;L-lactate;human intestinal fatty acid binding protein;Amphiregulin;Phosphorylated Phosphoinositide 3-Kinase, p-PI3K;Phosphoinositide 3-Kinase, PI3K;Phosphorylated Protein Kinase B, p-AKT;Protein Kinase B, AKT; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cleaved Caspase-3;Bcl-2-Associated X Protein, Bax;B-cell Lymphoma 2 Protein, Bcl-2;Tumor Necrosis Factor-a , TNF-a;Interleukin-6, IL-6;Interleukin-10, IL-10;Interleukin-1 Beta, IL-1ß; | — |
Countries
China
Contacts
Public ContactJun Zhou
The Affiliated Hospital of Southwest Medical University
Outcome results
None listed