ventilator-induced diaphragmatic dysfunction
Conditions
Interventions
Control group:The implementation of routine nursing, mainly for analgesia and sedation, routine respiratory therapy and pulmonary rehabilitation.
Interventional group:The intervention program of sequential multi-sensory stimulation based on sensory integration theory to prevent ventilator-associated diaphragmatic dy
Sponsors
Affiliated hangzhou first people's hospital, zhejiang university school of medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.older than 18 years old; 2.expected mechanical ventilation time = 48 hours; 3.APACHE II score 15-25 points; 4.hemodynamic stability ( norepinephrine dosage < 0.1µg / kg / min; 5.voluntary participation, obtained the legal representative to sign the informed consent;
Exclusion criteria
Exclusion criteria: 1.patients with diaphragmatic dysfunction before mechanical ventilation; 2.patients with a history of neuromuscular diseases ( such as myasthenia gravis, amyotrophic lateral sclerosis, etc. ); 3.severe cognitive dysfunction ( MMSE < 10 points ); 4.severe visual / hearing impairment ( affecting stimulus perception ); 5.expected survival time < 72 hours; 6.pregnant women; 7.participants in other interventional clinical trials;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ventilator induced diaphragm dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Respiratory mechanics index : maximum inspiratory pressure ( cmH2O ) ; breathing shallow fast index ( times / min / L ) ; airway resistance ( cmH2O / L / s );Mechanical ventilation time ( hours ) ; the success rate of weaning ( % ) ; iCU hospitalization time ( days ) ; in-hospital mortality ( % );Psychological state index :Hospital Anxiety Depression Scale, HADS; | — |
Countries
China
Contacts
Public ContactWang Yifeng
Affiliated hangzhou first people's hospital, zhejiang university school of medicine
Outcome results
None listed