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Study on the Mechanism of Time-Dependent Electrical Stimulation in Improving Function and Enhancing Neural Plasticity after Spinal Cord Injury

Study on the Mechanism of Time-Dependent Electrical Stimulation in Improving Function and Enhancing Neural Plasticity after Spinal Cord Injury

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500111638
Enrollment
Unknown
Registered
2025-11-04
Start date
2025-11-10
Completion date
Unknown
Last updated
2025-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal cord injury

Interventions

Intervention group:Conventional rehabilitation plus TI stimulation
Control group:Conventional rehabilitation plus sham TI stimulation

Sponsors

The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Focal spinal diseases caused by trauma or non-traumatic, non-progressive diseases (such as hemorrhage, benign tumors, etc.). 2.Age 18 to 75 years old; 3.Stable condition with no severe complications; 4. Recovery at least 6 months after spinal cord injury; 5.Lesions at the L1 level or above, based on ASIA injury classification, with retention of sacral function; 6. Clear consciousness, able to communicate normally, and able to cooperate with rehabilitation treatment; 7. Voluntary participation in this clinical trial and signing the informed consent form.

Exclusion criteria

Exclusion criteria: 1.Patients with unstable vital signs and unable to undergo research; 2.Patients with increased intracranial pressure and acute stroke patients; 3. Patients with metal implants in the brain, those with implanted pacemakers or cochlear implants; 4. Patients under deep sedation caused by general anesthetics (such as propofol) or central acting sedatives (such as benzodiazepines, opioids); 5. Patients with frequent arrhythmias and frequent epilepsy; 6. Patients with a history of mental illness, drug abuse and alcoholism; 7. Patients undergoing other neuroregulation treatments (such as transcranial magnetic stimulation).

Design outcomes

Primary

MeasureTime frame
LEMS;—

Secondary

MeasureTime frame
WISCI-II Score;SCIM;Muscle function;Changes in HbO2;EEG indicators;Resting-state blood oxygen level-dependent activity;Modified Ashworth Scale Score;American Spinal Injury Association Injury Classification;—

Countries

China

Contacts

Public ContactMin Su

The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)

sumin@suda.edu.cn+86 177 1266 1015

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026