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A Mechanistic Study on How Buccal Acupuncture Alleviates Intra-operative Pain in HIFU Patients by Attenuating Inflammation via the TLR4/NF-?B Pathway

A Mechanistic Study on How Buccal Acupuncture Alleviates Intra-operative Pain in HIFU Patients by Attenuating Inflammation via the TLR4/NF-?B Pathway

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500111623
Enrollment
Unknown
Registered
2025-11-03
Start date
2025-11-04
Completion date
Unknown
Last updated
2025-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adenomyosis

Interventions

Buccal acupuncture group:Buccal acupuncture therapy+Intravenous sedation and analgesia
Control group:Intravenous sedation and analgesia

Sponsors

Liuzhou Hospital of Guangzhou Women and Children's Medical Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Age: 18 to 50 years old, meeting the diagnostic criteria for adenomyosis 2. It has indications for HIFU treatment 3. Those who agree to participate in this research project and sign the informed consent form

Exclusion criteria

Exclusion criteria: 1.Those with concurrent autoimmune system diseases or malignant tumors of the uterus and ovaries 2. Patients with severe diseases in other systems such as the heart, liver and kidneys 3. Those with acute inflammation in the pelvic cavity or throughout the body 4. Women who are pregnant, breastfeeding or have the need to give birth within half a year 5. Those who cannot establish a HIFU safe passage 6. Those who cannot assume the prone position 7. There is inflammation or damage at the acupoint operation site 8. Those who are afraid of needles 9. Unable to cooperate or unwilling to collaborate for various reasons

Design outcomes

Primary

MeasureTime frame
Mean intraoperative VAS pain score;

Secondary

MeasureTime frame
Number of intraoperative sufentanil boluses and postoperative analgesic consumption;Vital signs (mean arterial pressure, heart rate, respiratory rate, oxygen saturation);VAS pain score at 2 h postoperatively;Inflammatory markers;

Countries

China

Contacts

Public ContactQiong Wang

Liuzhou Hospital of Guangzhou Women and Children's Medical Center

853810058@qq.com+86 772 220 5095

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026