Schizophrenia
Conditions
Interventions
Real stimulus:a-iTBS real intervention
pseudo-stimulation:Sham a-iTBS intervention
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Meet the diagnostic criteria for schizophrenia in the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition, DSM-5); 2) Age between 18 and 60 years; 3) Patients have received current medication treatment for at least 4 weeks with stable psychiatric symptoms, and are currently able to cooperate with iTBS therapy; 4) Positive and negative symptom scales scores should not exceed 5 points for: P1 Delusions, P3 Hallucinatory Behaviors, P5 Grandiosity, P6 Suspicion/Paranoia, G9 Abnormal Thought Content; 1.and should not exceed 4 points for: P2 Disorganized Thinking; 5) Obtain written informed consent from patients and their families.
Exclusion criteria
Exclusion criteria: 1) Patients with severe physical or neurological disorders, or those exhibiting significant abnormalities in biochemical indicators, electroencephalogram (EEG), or electrocardiogram (ECG); 2) Individuals displaying demonstrable negative, impulsive, or disruptive behaviors that impair examination compliance; 3) Subjects deemed by investigators to pose high suicide or violent risks; 4) Participants who received electroconvulsive therapy or magnetic stimulation within three months prior to enrollment; 5) Those with claustrophobia making MRI scanning inadvisable; 6) Patients with implanted metallic or electronic devices such as intracranial metal objects, cochlear implants, cardiac pacemakers, or stents; 7) Individuals at risk of epileptic seizures, including history of cranial trauma, alcohol abuse, abnormal EEG patterns, MRI evidence of brain structural abnormalities, or family epilepsy history; 8) Pregnant women, those planning pregnancy, or those with unanticipated pregnancy risks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Electrophysiological indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| PANSS;Neuropsychological measurements related to cognitive behavior; | — |
Countries
China
Contacts
Public ContactRong Wang
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed