Mild cognitive impairment in type 2 diabetes
Conditions
Interventions
Augmented Reality-based intervention group(iTaiChi group):Augmented Reality-based intervention group was provided with AR glasses and AI Tai Chi instructor guidance system.
Conventional Tai Chi intervention group(TaiChi group):The conventional Tai Chi intervention group is provided with experienced Tai Chi instructors for on-site guidance.
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Community-dwelling adults with type 2 diabetes mellitus complicated by mild cognitive impairment, 2. Who can understand and cooperate to complete the Montreal Cognitive Assessment (MoCA) and other relevant assessment tests, 3. Aged between 45 and 75, 4. Whose current hypoglycemic treatment plan has been stable for more than 2 months, 5. And who have given informed consent and are willing to participate.
Exclusion criteria
Exclusion criteria: 1. Other types of diabetes: such as type 1 diabetes, gestational diabetes, etc. 2. Neurological diseases: such as Alzheimer's disease, Parkinson's disease, post-stroke sequelae, etc. 3. Severe heart and lung diseases: such as uncontrolled hypertension, coronary heart disease, etc. 4. Use of drugs that affect cognitive function: such as certain antiepileptic drugs, antipsychotic drugs, etc. 5. Neurological diseases related to dementia or having suffered from depression within the past 2 years; mental retardation, mania, depression, schizophrenia, etc.; 6. Central nervous system diseases, including brain trauma, intracranial hemorrhage, acute cerebral infarction, etc.; 7. Occupying lesions such as severe sinusitis, nasal and sinus polyps, tumors in the skull base or nasopharynx; congenital diseases and trauma of the nose, jaw, face and skull base that affect olfaction. There were no symptoms of upper respiratory tract infection on the day of MR examination, including nasal congestion, runny nose, fever, etc.; 8. Acute complications of diabetes, including diabetic ketoacidosis, hyperglycemic hyperosmolar state, hypoglycemic coma, etc.; 9. MRI contraindications, such as implanted metal prostheses in the body, claustrophobia, etc. 10. Pregnant and lactating women; 11. Patients with severe functional disorders of important organs such as heart, liver, kidney, etc. 12. Patients with severe visual or hearing impairments that affect communication and motor learning. 13. Patients who are unable to perform normal activities. 14. Those who are participating in other clinical trials that may affect the results of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in Montreal Cognitive Assessment(MoCA) scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in anthropometry;Changes in body composition;Changes in indicators related glucose metabolism;Changes in clinical biochemical indicators;Changes in indicators related to the experimental paradigm;Changes in sarcopenia-related indicators;Changes in exercise-related indicators;Changes in dynamic blood glucose indicators;Changes in the olfaction function;Changes in genomics;Changes in metagenomics;Changes in epigenomics;Changes in proteomics;Changes in transcriptomics;Changes in metabolomics;Changes in lipdomics;Changes in cognitive function;Changes in psychological status;Changes in sleep quality;Changes in indicators related to Traditional Chinese Medicine;Changes in indicators related to cranial magnetic resonance imaging; | — |
Countries
China
Contacts
Public ContactHuating Li
Shanghai Sixth People's Hospital
Outcome results
None listed