Oxygen deficiency
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age range of 18-70 years old; 2. Obesity (body mass index >= 28 kg/m^2); 3. Planned sedation gastroscopy examination; 4. Sign the informed consent form; 5 American Society of Anesthesiologists (ASA) classification <= Grade II.
Exclusion criteria
Exclusion criteria: 1. Coagulation dysfunction or tendency towards nosebleeds; 2. Diagnosed with heart disease (heart failure, angina pectoris, myocardial infarction, arrhythmia, etc.); 3. Lung diseases (asthma, bronchitis, chronic obstructive pulmonary disease, pulmonary bullae, pulmonary embolism, pulmonary edema, lung cancer, etc.) and upper respiratory tract infections; 4. Pregnant women; 5. Suffering from liver or kidney diseases; 6. Emergency surgeries or procedures; 7. Increased intracranial pressure and multiple injuries; 8. Does not agree to participate in this experiment; 9. Individuals without civil capacity; 10. Pairs of drugs used in the study are allergic.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Low oxygen levels (blood oxygen saturation 75% <= SpO2<90% and duration<60 seconds) during the examination period Incidence rate.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of subclinical respiratory depression (90% <= SpO2 <= baseline -5%);Lowest SpO2 value;Average duration of hypoxic events (SpO2 < 90%);Recovery room stay duration;VAS score;Incidence of hypoxic events requiring intervention; | — |
Countries
China
Contacts
The First Affiliated Hospital of Nanchang University