High nicotine dependence caused by long-term and heavy smoking
Conditions
Interventions
The high-concentration dexmedetomidine and ropivacaine group (0.33% ropivacaine combined with 1 microgram/kg dexmedetomidine, 20 ml, DR2 group):Perform paravertebral nerve block using 0.33% ropivacain
Control group: Ropivacaine group (20 ml of 0.33% ropivacaine, R group):20 ml of 0.33% ropivacaine for paravertebral nerve block
low-dose dexmedetomidine and ropivacaine group (20 ml of 0.33% ropivacaine combined with 0.5 ug/kg dexmedetomidine, DR1 group):0.33% ropivacaine combined with 0.5 micrograms per kilogram dexmedetomidi
Sponsors
Liaocheng People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.ASA Grade II- III; 2. Patients aged 40 to 65 with high nicotine dependence (HND, Fagerstrom score >=6); 3. Master the operation of the PCA pump and the relevant postoperative scoring methods; 4. Patients scheduled to undergo thoracoscopy under general anesthesia with bronchotracheal intubation.
Exclusion criteria
Exclusion criteria: 1.Patients undergoing thoracoscopic surgery with a nicotine dependence score of Fagerstrom 30kg/m ²; 4. A history of ischemic heart disease within the last 6 months, with a heart rate of less than 50 beats per minute or second-degree or third-degree atrioventricular block; 5. Insufficiency of liver and kidney functions; 6. Neuropsychiatric disorders; 7. Long-term use of antihypertensive drugs or beta-adrenergic receptor blockers before the operation (more than 3 months); 8. Known to be allergic to the research drug; 9. Have a history of chronic pain and have been taking analgesic drugs for a long time (more than 3 months)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The dosage of sufentanil after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient demographic data and general intraoperative conditions;Perioperative hemodynamic changes;NRS score;LOS score;BCS score;FAS classification; | — |
Countries
China
Contacts
Public ContactGao Xiujuan
Liaocheng People's Hospital
Outcome results
None listed