Postoperative Nausea and Vomiting
Conditions
Interventions
Intervention group:Before anesthesia induction, 1mg of tapentadol was intravenously infused via a pump (Tapentadol is a colorless and clear liquid
1mg of tapentadol should be diluted to 20ml, and the administration should be completed within 10 minutes).
Control Group:Before anesthesia induction, the same dose of normal saline was intravenously infused via a pump, and the administration was completed within 10 minutes.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.American Society of Anesthesiologists (ASA) Physical Condition Classification I-II; 2. Age: 18 to 65 years old; 3. Female patients scheduled for laparoscopic cholecystectomy.
Exclusion criteria
Exclusion criteria: 1. Allergic to or having contraindications to the investigational drugs; 2. Preoperative lack of communication ability (coma, deep dementia or language disorder); 3. Severe hypertension (systolic blood pressure >=180mmHg, diastolic blood pressure >=110mmHg) 4. Have a history of serious liver, kidney, lung or heart diseases; 5. There is a history of schizophrenia, epilepsy, Parkinson's disease or myasthenia gravis before the operation; 6. Have a history of chronic opioid use; 7. Take CYP2D6 and CYP3A inhibitors two weeks before the operation; 8. Pregnant and lactating women; 9. Combined with gastrointestinal peristaltic dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The overall incidence of postoperative nausea and vomiting (PONV) within 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of nausea and vomiting within 0-6 hours and 6-24 hours after the operation;The number of times nausea or vomiting occurred within 24 hours after the operation;The severity of nausea and vomiting within 24 hours after the operation;The remedial dosage of antiemetic and analgesic drugs within 24 hours after the operation;The time of first getting out of bed;Time of first meal;The pain scores at 6 hours, 12 hours and 24 hours after the operation;The occurrence of complications such as respiratory depression and urinary retention 24 hours after the operation;The time of the first anal exhaust/defecation;The occurrence of intraoperative hypotension and bradycardia;QoR-15 score 24 hours after the operation;Postoperative discharge time; | — |
Countries
China
Contacts
Public ContactXiaoqiang Li
West China Hospital, Sichuan University
Outcome results
None listed