None
Conditions
Interventions
Experimental Group:The patients were divided into two groups based on age: the adult group (<65 years old) and the elderly group (=65 years old). The test drug is disodium phosphopropofol for injectio
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-65 years old (inclusive of 18 years old but exclusive of 65 years old) or 65-80 years old (inclusive of 65 years old and 80 years old), American Society of Anesthesiology (ASA) physical constitution classification I-II; 2. Patients who need tracheal intubation for elective general anesthesia surgery; 3. Operation time >= 30 minutes; 4. body mass index (BMI) = 30kg/m ²; 5. The serum alkaline phosphatase level (ALP) is normal
Exclusion criteria
Exclusion criteria: Those with any of the following circumstances will not be considered as selected cases: 1.Patients with ASA grade III or above; 2. Patients with hypertension and unsatisfactory blood pressure control (systolic blood pressure >= 180mmHg or diastolic blood pressure >=100mmHg); 3. Patients with expected difficult airways or those requiring double-lumen tracheal intubation; 4. Patients who have successfully undergone two or more tracheal intubations during induction; 5. Patients who are obese (BMI>=30), underweight (BMI =100kg; 6. Patients with a history of severe asthma, allergic diseases and severe drug allergies; 7. Patients who have been using sedative-hypnotic drugs and anti-anxiety and anti-depression drugs for a long time; 8. Pregnant and lactating patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED 50 and ED95 of inhibiting hemodynamic response to tracheal intubation during induction of general anesthesia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of loss of consciousness; | — |
Countries
China
Contacts
Public ContactZhiyu Geng
Department of anesthesiology, Peking University First Hospital
Outcome results
None listed