Heart failure
Conditions
Interventions
Intervention Arm:Patients randomized within 24 hours of hospitalization underwent dry weight assessment exclusively based on BIA(Bioelectrical Impedance Analysis) measurements. Fluid status was evalua
values below -1.1L signaled over-diuresis, requiring reduction in diuretic intensity. Daily BCM measurements were obtained throughout hospitalization, with diuretic regimens adjusted in real-time base
Control Arm:The control arm received conventional decongestion therapy reflecting real-world practice patterns, where diuretic titration was guided by integrated assessment of clinical and laboratory
Sponsors
The First Affiliated Hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years; 2. Hospitalization for acute decompensated heart failure or worsening heart failure symptoms; 3. Established prior diagnosis of chronic heart failure; 4. Clinical evidence of fluid overload (e.g., pulmonary rales, peripheral edema, jugular venous distension, ascites, pulmonary congestion, or radiographic pulmonary edema) requiring intravenous diuretic therapy as determined by the treating physician; 5. Provision of written informed consent
Exclusion criteria
Exclusion criteria: 1. Have other serious diseases that may endanger survival within 3 months, and have readmission plans (including revascularization, device implantation, etc.) within 3 months after discharge; 2. The history of two or more electrolyte disturbances in the past year; 3. Severe renal insufficiency (serum creatinine > 442µmol/L or eGFR < 30), nephrotic syndrome or receiving long-term regular dialysis; 4. Severe hypothyroidism and decompensated cirrhosis; 5. Lower extremity cellulitis, severe varicose veins, lymphedema, or deep vein thrombosis; 6. Pregnant or bedridden patients unable to take weight measurement; 7. Patients with fever or diarrhoea.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A composite endpoint of HF readmission and all-cause death within 3 months after discharge; | — |
Secondary
| Measure | Time frame |
|---|---|
| Re-hospitalized in March due to heart failure;Cardiovascular-related deaths in March;All cause death occurred in 3 months;The change of KCCQ quality of life score from baseline to discharge and 3 months after discharge;Dose of diuretics used during hospitalization;Dyspnea and changes in overall condition at 72 hours after admission (VAS scale);The incidence of hypotension during hospitalization;The incidence of electrolyte imbalance during hospitalization and follow-up period;Incidence of acute kidney injury during hospitalization; | — |
Countries
China
Contacts
Public ContactLu Yanmei
The First Affiliated Hospital of Xinjiang Medical University
Outcome results
None listed