Postoperative complications of cardiac surgery
Conditions
Interventions
Trial Group/ Morphine Group:Perioperative morphine analgesia strategy: Morphine hydrochloride injection is used for analgesia. Administration via continuous intravenous infusion combined with PRN dosi
Control Group/ Fentanyl Group:Perioperative fentanyl-based analgesia strategy: The attending physician selects from the following fentanyl analogs based on patient condition, drug availability, and cl
Sponsors
Mianyang Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria for this study included age ranging from 18 to 80 years old, undergoing elective cardiac surgery (valve surgery, coronary artery bypass grafting or combined surgery), with an expected postoperative mechanical ventilation time of = 6 hours, and the patient or their legal representative signing the informed consent form.
Exclusion criteria
Exclusion criteria: Patients who have been using opioids for more than three months before surgery, are allergic to morphine or fentanyl, have severe liver and kidney dysfunction (Child-Pugh C grade for liver function, eGFR < 30 ml/min/1.73 m^2 for kidney function), have severe respiratory system diseases (COPD GOLD 4 grade), need ECMO support due to severe intraoperative complications, and have an expected survival period of less than 28 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Re-intubation rate within 48 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement degree of dyspnea;Mechanical ventilation time;Comprehensive efficacy evaluation (including satisfaction with analgesic effect, patient comfort score, and healthcare provider assessment); | — |
Countries
China
Contacts
Public ContactXu Jinlong
Mianyang Central Hospital
Outcome results
None listed