severe trauma
Conditions
Interventions
Ketamine injection group:After patients who meet the enrollment conditions are enrolled (ketamine injection group): After completing the necessary pre-hospital first aid assessment and first aid measu
use the analgesic efficacy evaluation tool to evaluate pain treatment after 5 minutes: Pain Management Index: The evaluation of pain treatment and adjustment of methods can be dynamically managed acco
when the efficacy index is <50%, it indicates that the analgesic effect is poor [7,37]. If the pain intervention is ineffective, an additional dose of 0.3-0.5 can be added. mg/kg IV, and re-evaluate t
the pre-hospital treatment method is determined by the clinician. , until necessary rescue measures and/or relevant inspections are complete
Sponsors
Fushun County People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old and 16 points; 3. Patients with pain ratings of grade II or III on NRS or Wong Baker scales; 4. Obtain informed consent from patients or their families.
Exclusion criteria
Exclusion criteria: 1. Age under 18 years old, or age over 75 years old; 2. Pregnancy or lactation; 3. Using single oxidase inhibitors; 4. Severe and existing substantial liver disease accompanied by clinically significant portal hypertension, Child Pugh C-grade cirrhosis, or acute liver failure; 5. Patients with acute or chronic renal insufficiency requiring dialysis treatment; 6. Severe traumatic brain injury, brain tumor, increased intracranial pressure, cerebrovascular accident, coma, status epilepticus, etc; 7. Patients with a history of alcohol or drug abuse; 8. Any situation that hinders the correct assessment of cognitive function, such as language and sensory disorders or mental disorders (language difficulties or organic dysfunction) and inability to complete the Wong Baker scale; 9. Unable to obtain informed consent or authorization; 10. Participate in other exploratory clinical trials within one month prior to screening; 11. Known allergies to opioid and ketamine drugs; 12. Patients with severe hemodynamic instability, severe shock, and multiple organ failure; 13. Patients with severe ARDS;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of pre hospital emergency time within the target analgesia range;Study the duration of onset of target analgesia during drug administration and the total dosage of the drug; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reaction incidence rate; | — |
Countries
China
Contacts
Public ContactQiang Li
Fushun County People's Hospital
Outcome results
None listed