Postoperative pain and quality of recovery in patients with gynecological malignant tumors undergoing open surgery.
Conditions
Interventions
Quadratus lumborum plane block above the arcuate ligament combined with general anesthesia.:Preoperatively: Ultrasound-guided bilateral transversus abdominis plane block at the arcuate ligament level,
vasopressors administered as needed to maintain hemodynamic stability.
Postoperatively: Patient-controlled intravenous analgesia (PCA) was provided
if the maximum number of PCA boluses was reached without adequate pain relief, oral tramadol was administered as rescue analgesia.
Simple General Anesthesia:Preoperatively: Pure general anesthesia (no nerve block).
Intraoperatively: Tracheal intubation with intravenous infusion of propofol and remifentanil for maintenance, with a
vasopressors administered as needed to maintain hemodynamic stability.
Postoperatively: Local infiltration of 20 mL of 1.33% liposomal bupivacaine at the incision site
patient-controlled intravenous analgesia (PCA) was provided
Sponsors
Gansu Provincial Maternity and Child-Care Hospital(Gansu Provincial Central Hospital)
Eligibility
Sex/Gender
Female
Age
35 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 35 and 70 years old; 2.ASA classification at grade ? - ?; 3. BMI < 30 kg/m^2; 4. Without mental illness or cognitive dysfunction; 5.All patients were informed of the research content before being included in the study and voluntarily signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of drug allergies. 2. There is an infection at the operation site. 3.Coagulation dysfunction. 4. Severe cardiopulmonary diseases or liver and kidney dysfunction. 5. Those who are dependent on analgesic drugs and have a history of chronic pain in the past. 6. The patient has participated in other clinical trials in the past four weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rest/activity pain intensity at different time points after surgery;The total consumption of rescue analgesics within 72 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative Quality of Recovery Scale (QoR-15 Scale);Postoperative functional recovery indicators (including intestinal function recovery time, time to first ambulation, and length of hospital stay);Postoperative Analgesia Satisfaction Score (Likert 5-Point Scale: Very Dissatisfied - Very Satisfied);Serum Stress Markers (Cortisol, Blood Glucose, and White Blood Cell Level) Detected at 24 Hours Postoperatively;Postoperative Immune Function Indicators at 72 Hours (CRP, CD3^+, CD4^+, CD4^+/CD8^+ Ratio, NK Cells);Incidence of Chronic Pain at 3 Months and 6 Months Postoperatively; | — |
Countries
China
Contacts
Public ContactLiu Fengjuan
Gansu Provincial Maternity and Child-Care Hospital(Gansu Provincial Central Hospital)
Outcome results
None listed