Mechanical ventilation in ICU
Conditions
Interventions
Control group:Dexmedetomidine + Propofol
Treatment group:Cyclophorol
Sponsors
The Second Hospital,University of South China
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients requiring mechanical ventilation via endotracheal intubation, with an anticipated need for at least 24 hours of sedation post-randomisation; 2. Target RASS sedation score within 0 to -4 points; 3. Age 18 years <= age <= 80 years, gender unrestricted; 4. Body mass index (BMI) 18 kg/m² <= BMI <=30 kg/m²; 5. The patient or their family members fully understand the purpose and significance of this trial, voluntarily participate in this clinical trial, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1.known allergies to eggs, soy products, opioids and their relief drugs, propofol, cyclopofol, dexmedetomidine, etc. Propofol, cyclopofol, dexmedetomidine, opioids and their relief drugs contraindicated; 2.Patients who have been sedated for more than 3 days in the ICU or in the general ward before being transferred to the ICU; 3.During the screening period, patients with severe cardiovascular, neurological/psychiatric, liver and kidney diseases were assessed by the researchers as having great risk of sedation/anesthesia, so they should not participate in the study; 4.near-death state, or the expected survival period is not more than 72 hours; 5.Pregnant or lactating women; 6.Other conditions in which the investigator determines that the patient is not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Average sedation attainment rate;Mean time to reach sedation target;recovery time;extubation time;Mechanical ventilation time;length of ICU stay; | — |
Countries
China
Contacts
Public ContactCaihong Yan
The Second Hospital,University of South China
Outcome results
None listed