Undergo hysteroscopic surgery
Conditions
Interventions
Oliceridine group:Administer propofol at a dose of 2 mg/kg based on patient body weight, followed by intravenous administration of remimazolam 1 mg
ensure slow injection over approximately 10 seconds. Begin hysteroscopic procedures once the MOAA/S score is =60 mmHg, with fluctuations not exceeding 20% of baseline
keep heart rate between 50 and 100 beats per minute, with fluctuations not exceeding 20% of baseline. If significant increases in MAP or heart rate (exceeding 20% above baseline) occur, indicating ina
Sufentanill group:Administer propofol at a dose of 2 mg/kg based on patient body weight, followed by intravenous injection of sufentanil 5 µg
Sponsors
Mindong Hospital of Ningde City
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18~65 years, BMI (Body Mass Index) 18<=BMI<=27 kg/m^2; 2. ASA (American Society of Anesthesiologists) grade: I~II, estimated operation time <1 hour; 3. Patients agree to participate in this study and have good compliance; 4. The patient underwent hysteroscopic diagnosis and treatment, and the anesthesia method was non-intubated general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Suffering from poorly controlled hypertension, diabetes, or airway-related diseases such as asthma; 2. Severe liver and kidney insufficiency; 3. History of allergy to anesthetics; 4. Regular long-term use of glucocorticoids, analgesics, or psychiatric drugs within the past 3 months; or a history of drug abuse; 5. Those who refuse to participate in this study or have difficulties in communication; 6. Subjects with any other factors that the investigator believes are inappropriate for participation in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of respiratory depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of body movement;Incidence of nausea and vomiting;PACU Discharge Time; The number of additional doses and dosage of analgesic drugs (oliceridine and sufentanil); The number of doses and dosage of tramadol;The dosage of propofol;Other adverse reactions and incidence rate;Incidence of hypotension;QoR-15 scale score on the first day after surgery;Pittsburgh sleep quality index (PSQI) score three months after surgery;Levels of inflammatory markers IL-6 and TNF-a before surgery and on postoperative day 1;Arterial partial pressure of oxygen, partial pressure of carbon dioxide, pH, and oxygenation index at post-anesthesia and at the end of surgery; | — |
Countries
China
Contacts
Public ContactLiang Yagui
Mindong Hospital of Ningde City
Outcome results
None listed