The four risk factors in the Apfel risk score system are female sex, history of PONV or motion sickness, nonsmoking status, and postoperative opioid use. Gastrointestinal cancer patients presenting with at least three of these risk factors were included
Conditions
Interventions
Anrikefon group:Anrikefon analgesia
Sponsors
Zhejiang Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.aged 18-80 years; 2.ASA physical status of I-III; 3.Apfel simplified risk score for PONV >= 3;
Exclusion criteria
Exclusion criteria: 1.Central nervous system diseases: Subjects with conditions such as epilepsy, Parkinson's disease, or other CNS disorders that may cause nausea and vomiting, including but not limited to traumatic brain injury, intracranial space-occupying lesions, and intracranial aneurysms. 2.History of severe drug allergy: Subjects with a history of severe drug allergies or a known allergy to any of the protocol-specified study medications (e.g., Anruikefen, 5-HT3 receptor antagonists, or dexamethasone). 3.Severe renal impairment: Defined as a glomerular filtration rate (GFR) <= 30 mL/min. 4.Preoperative use of medications with known antiemetic properties: Use of such medications within 2 weeks prior to surgery. 5.Psychiatric disorders or inability to communicate. 6.Pregnant or lactating women. 7.Refused to participate in the study. 8.Underwent laparoscopic exploratory surgery only.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Postoperative Nausea and Vomiting (PONV); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of Nausea ,Incidence of Vomiting;Proportion of patients using antiemetic medication;Time to First Flatus , Time to First Defecation , Time to First Ambulation;Respiratory depression incidence;24-hour Intravenous Fluid;Length of Hospital Stay,Patient Satisfaction;Postoperative Pathological Stage;Time to the first occurrence of either vomiting or antiemetic administration;QoR-15 Score;Proportion of subjects experiencing severe PONV;Pain Scores , Rescue Analgesia , Opioid Consumption;Clavien-Dindo Classification;EQ-5D-5L questionnaire; | — |
Countries
China
Contacts
Public ContactXu Pingbo
Zhejiang Cancer Hospital
Outcome results
None listed