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The prognostic significance and molecular mechanism of HPV-independent p16 overexpression in head and neck squamous cell carcinoma

The prognostic significance and molecular mechanism of HPV-independent p16 overexpression in head and neck squamous cell carcinoma

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500111401
Enrollment
Unknown
Registered
2025-10-30
Start date
2025-11-03
Completion date
Unknown
Last updated
2025-11-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head and neck squamous cell carcinoma

Interventions

Review Group:None
Foresight Team:None

Sponsors

Beijing Stomatological Hospital , Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age: Over 18 years old, gender not limited; 2.Patients with primary squamous cell carcinoma confirmed by pathological diagnosis; 3.There is no previous history of radiotherapy or radical surgery; 4.The postoperative pathological report of the primary lesion specimen has undergone p16 immunohistochemical detection; 5.The tumor occurred in the oral cavity and oropharynx.

Exclusion criteria

Exclusion criteria: 1.Those who are unable to obtain complete clinical data required for the research; 2.Women who are pregnant or breastfeeding; 3.People with mental or intellectual disabilities.

Design outcomes

Primary

MeasureTime frame
Disease free survival;p16 status;—

Secondary

MeasureTime frame
Overall survival;—

Countries

China

Contacts

Public ContactZhien Feng

Beijing Stomatological Hospital , Capital Medical University

jyfzhen@126.com+86 10 57099150

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026