Oral tongue squamous cell carcinoma
Conditions
Interventions
follow-up group:-
PORT group:postoperative radiotherapy
Sponsors
The second affiliated hospital of Zhejiang University school of medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Age >=18 and <= 70 years, gender not restricted; 2.Previously untreated patients (no prior radiotherapy, chemotherapy or targeted therapy); 3.Complete resection of the tumor by the naked eye and no residual tumor found in postoperative pathology; 4.Lesions limited to the anterior 2/3 of the tongue (mobile part of the tongue); 5.Postoperative pathology confirmed as tongue squamous cell carcinoma; 6.According to the 8th edition of AJCC, the pathological TNM stage is T1-2N0M0; 7.At least one risk factor: lymphovascular invasion, perineural infiltration, moderately differentiated or poorly differentiated; 8.Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2; 9.No participation in other clinical trials within 4 weeks before screening; if cases failed screening in other trials but meet the requirements of this trial, they can be included;
Exclusion criteria
Exclusion criteria: 1.Patients with invasion of the oropharynx, floor of the mouth, cheek, neck or other organs; 2.Received chemotherapy or other anti-tumor drugs; 3.Previously received radiotherapy to the head and neck; 4.Patients with active autoimmune diseases requiring systemic treatment; 5.Pregnant or lactating women; 6.Patients with acute infections that are difficult to control; 7.Drug addicts, drug abusers, long-term alcoholics and AIDS patients; 8.Patients with other known invasive malignant tumors (except those with no evidence of tumor recurrence after treatment and a duration of more than 2 years); 9.Other conditions that the investigator deems to hinder the patient's participation in this trial;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3-years DFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| 5-years OS;5-years DFS;toxic events;Quality of Life; | — |
Countries
China
Contacts
Public ContactQichun Wei
The second affiliated hospital of Zhejiang University school of medicine
Outcome results
None listed