Carotid artery stenosis
Conditions
Interventions
Sponsors
Zhongshan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 18 and 85 years; 2.Carotid artery stenosis >=70% (asymptomatic) or >=50% (symptomatic), as confirmed by ultrasound, CTA, or MRA; 3.Scheduled for carotid endarterectomy (CEA) with perioperative antiplatelet therapy using either aspirin or aspirin combined with clopidogrel; 4.No known history of allergy or resistance to the relevant medications; 5.Provision of signed informed consent
Exclusion criteria
Exclusion criteria: 1. History of intracranial hemorrhage; HAS-BLED score >=3; platelet count 1.5; or other conditions indicating a high risk of bleeding; 2.Severe systemic diseases, including advanced malignant tumors, end-stage liver disease (Child-Pugh C), end-stage renal disease (eGFR 10 mg/day prednisone equivalent), immunosuppressants, biologic agents (e.g., IL-1ß antibodies), PCSK9 inhibitors, or participation in another clinical trial within the past 6 months; 5.Significant hematologic disorders: including primary thrombocytopenia, leukemia, severe anemia (Hb < 80 g/L), or active hemorrhagic diseases; 6.Pregnant or lactating women; 7.Individuals with limited study compliance, including those with psychiatric disorders, cognitive impairment, or other conditions preventing completion of follow-up and biospecimen collection; 8.Any other conditions deemed unsuitable for CEA surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hemorrhagic events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of ischemic events; | — |
Countries
China
Contacts
Public ContactLixin Wang
Zhongshan Hospital Affiliated to Fudan University
Outcome results
None listed