Cognitive Impairment
Conditions
Interventions
Individualized Nutrition Therapy Intervention Group:Patients received a personalized nutrition support protocol. Clinical pharmacists customized energy and protein targets based on the patients disea
patients with insufficient oral intake received whole-protein or short-peptide tube-feeding formulas, and those intolerant to or with insufficient enteral intake were supplemented with all-in-one pare
Conventional Nutrition Control Group:Patients received standard hospital diets, with physicians providing conventional nutrition intervention when necessary.
Sponsors
Wuxi No.2 People's Hospital
Eligibility
Sex/Gender
All
Age
80 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 80 years inpatients; 2.Presence of nutritional risk (NRS-2002 >= 3 points or MNA-SF <= 11 points); 3.Presence of cognitive impairment (MoCA score < 26).
Exclusion criteria
Exclusion criteria: 1. Severe intestinal dysbiosis; 2. Patients with severe infection requiring prolonged antimicrobial therapy; 3. Severe cardiac, pulmonary, hepatic, or renal dysfunction (evaluation criteria strictly follow international authoritative guidelines for defining severe organ dysfunction): 4. Cardiac function: NYHA Class IV or ACC/AHA Stage D; 5. Pulmonary function: GOLD Stage 3–4; 6. Hepatic function: Child-Pugh Class C or liver function tests more than twice the upper limit of normal; 7. Renal function: KDIGO Stage G4–G5; 8. Inability to complete follow-up or data collection; 9. Other reasons deemed unsuitable for participation by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment Scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini Nutritional Assessment - Short Form Scores;The Barthelindex Scores;The concentration ratio of ß-amyloid 42(Aß42) to ß-amyloid 40(Aß40) in serum;The concentrations of phosphorylated Tau 217(p-Tau217) in serum; | — |
Countries
China
Contacts
Public ContactYang Xin
Wuxi No.2 People's Hospital
Outcome results
None listed