The anesthesia of awake craniotomy
Conditions
Interventions
Remimazolam tosilate group :The groups was induced and maintained under anesthesia using remimazolam besylate as the primary sedative agents.
Propofol group:The groups was induced and maintained under anesthesia using propofol as the primary sedative agents.
Sponsors
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
Male
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients aged 18 to 65 (including the critical values) who received awake craniotomy; 2.The patient who voluntarily participates and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Severe preoperative intracranial hypertension, patients presenting with cerebral herniation, or those exhibiting consciousness or cognitive impairment. 2.Preoperative communication barriers, including severe aphasia (anomic, motor, or conductive) that impedes doctor-patient communication and precludes reliable intraoperative neurological monitoring. 3.Patients with a full stomach due to failure of strict preoperative fasting, or those complicated by elevated gastric pressure, intestinal obstruction, perforation, necrosis, or other significant digestive system disorders. 4.Patients with a body mass index (BMI) >30 kg/m^2, complicated by obesity hypoventilation syndrome (OHS) or obstructive sleep apnea syndrome (OSAS). 5.Patients unable to tolerate prolonged immobilization in a fixed position, such as those with spondylitis or arthritis. 6.Patients suffering from any of the following conditions: hypertension of grade 2 or higher, New York Heart Association (NYHA) class II or higher heart disease, systemic or critical organ infection, severe hepatic or renal insufficiency. 7.Anticipated difficult airway, status post-tracheostomy, upper airway obstruction (e.g., foreign body, snoring disease), nasopharyngeal abnormalities, other severe respiratory diseases, or heavy long-term smokers. 8.Patients with other concomitant major systemic organ dysfunction or infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to awakening;Agitation score; | — |
Countries
China
Contacts
Public ContactLlu Fuding, Peng Jun
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Outcome results
None listed