Colorectal cancer
Conditions
Interventions
Oliceridine group:0.4mg/kg of oliceridine plus saline to 100ml
Hydromorphone group:0.1 mg/kg of hydromorphone plus saline to 100ml
Sponsors
Peking University Shougang Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18–70 years old; 2. ASA grade I–III; 3. Undergoing colorectal cancer surgery under general anesthesia (with a midline incision >5 cm); 4. BMI is 18.5–29.9 kg/m^2 [BMI = weight (kg) / height (m)^2]; 5. The patient selects an analgesic pump for postoperative analgesia; 6. Ethical compliance, voluntary patient participation, and informed consent signed by the patient prior to surgery.
Exclusion criteria
Exclusion criteria: 1. Individuals who are allergic to the study drug; 2. Individuals with severe abnormalities in liver and kidney function (severe liver dysfunction: ALT, conjugated bilirubin, AST, ALP, total bilirubin, any of which is greater than twice the upper limit of normal; severe renal dysfunction: creatinine clearance rate <30 ml/min); 3. Patients with New York Heart Association Class II or above; 4. Individuals with severe respiratory diseases; 5. Individuals with a history of chronic pain; 6. Individuals with infection at the injection site; 7. Individuals with alcohol or drug abuse; 8. Individuals with opioid dependence; 9. Individuals with mental illnesses that interfere with pain perception and assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| QoR-15 scores at 48 hours and 72 hours after surgery;Pain scores during postoperative rest and activity;Postoperative rescue analgesic dose;Adverse reactions associated with opioids (nausea, vomiting, respiratory depression, itching, dizziness);Time of first getting out of bed;Time of intestinal function recovery; | — |
Countries
China
Contacts
Public ContactZhao Lin
Peking University Shougang Hospital
Outcome results
None listed