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Effect of Remifentanil on Bispectral Index (BIS) values in patients at different depths of anesthesia induced by propofol: A randomized controlled trial.

The influence of high-dose remifentanil concentration on the bispectral index of patients at different depths of anesthesia.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500111361
Enrollment
Unknown
Registered
2025-10-30
Start date
2025-11-01
Completion date
Unknown
Last updated
2025-11-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

none

Interventions

G1:4ng/ml remifentanil *2ug/ml propofol
G2:8ng/ml remifentanil *2ug/ml propofol
G3:16ng/ml remifentanil *2ug/ml propofol
G4:4ng/ml remifentanil *3ug/ml propofol
G5:8ng/ml remifentanil *3ug/ml propofol
G6:16ng/ml remifentanil *3ug/ml propofol
G7:4ng/ml remifentanil *6ug/ml propofol
G8:8ng/ml remifentanil *6ug/ml propofol
G9:16ng/ml remifentanil *6ug/ml propofol

Sponsors

The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients aged between 18 and 60 with ASA classification of grade I or II who are scheduled for elective surgery.

Exclusion criteria

Exclusion criteria: Patients with severe liver or kidney dysfunction, neuropsychiatric disorders, a history of psychotropic drug use, implanted pacemakers, thyroid diseases, allergies to remifentanil, propofol, or muscle relaxants, a BMI over 30 kg/m ^2, and those who were pregnant or lactating were excluded.

Design outcomes

Primary

MeasureTime frame
Bispectral index;

Secondary

MeasureTime frame
Mean arterial pressure;Heart rate;Electromyographic activity;Signal Quality Index;

Countries

China

Contacts

Public ContactGuo Xiaowen

The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)

guoxiaowen1315@hotmail.com+86 137 5712 3712

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026