Chronic pancreatitis
Conditions
Interventions
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18-60; 2. Diagnosed with chronic pancreatitis; 3. Fecal elastase (FE1) level <= 200 µg/g; 4. Still experiencing bloating and diarrhea symptoms after treatment with enteric-coated pancreatic enzyme capsules.
Exclusion criteria
Exclusion criteria: 1. Use of antibiotics or probiotics within 2 months; 2. Autoimmune pancreatitis; 3. Obstructive jaundice; 4. Uncontrolled malignant tumors; 5. Organic gastrointestinal diseases or history of gastrointestinal surgery; 6. Pregnancy or breastfeeding; 7. Mental disorders or other reasons preventing tolerance or cooperation with treatment; 8. Failure to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of Life; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of adverse events;pancreatic exocrine function;Small intestinal bacterial overgrowth (SIBO);Clinical symptoms and signs;Microbiota colonization rate;Gut microbiome metabolome;Gut microbiota composition;Gut virome;Inflammatory markers;Nutritional markers; | — |
Countries
China
Contacts
Public ContactDong Wu
Peking Union Medical College Hospital
Outcome results
None listed