Comparison of the effects of low thoracic paravertebral block versus epidural block on postoperative recovery quality in laparoscopic donor nephrectomy

Comparison of the effects of low thoracic paravertebral block versus epidural block on postoperative recovery quality in laparoscopic donor nephrectomy: A prospective randomized non-inferiority trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500111247

Enrollment

Unknown

Registered

2025-10-28

Start date

2025-11-10

Completion date

Unknown

Last updated

2025-11-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Living kidney transplant donor

Interventions

Group T:Epidural block

Group D:Direct-vision low thoracic paravertebral block via the arcuate ligament

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.Gender: not restricted, Age: 18–70 years, ASA Physical Status Classification: Grade I–III; 2.Scheduled to undergo laparoscopic living donor nephrectomy under general anesthesia;

Exclusion criteria

Exclusion criteria: 1.Preoperative use of anticoagulant drugs; 2.History of long-term opioid addiction or use of any analgesic drugs for more than 3 months; 3.Patients with allergies to drugs used in standardized anesthesia; 4.Patients with severe cardiovascular diseases, cerebrovascular diseases, or hematological diseases; 5.History of drug abuse or alcohol abuse; 6.Patients who have undergone previous thoracic or spinal surgery, or those with spinal deformity; 7.Patients with insufficient understanding of the QOR-15 score before surgery; 8.Local infection at the puncture site or systemic infection; 9.Patients who refuse to participate in the observation;

Design outcomes

Primary

Measure	Time frame
Postoperative 24-hour NRS pain score in ambulation;Total opioid consumption within 24 hours postoperatively;	—

Secondary

Measure	Time frame
Time to first postoperative opioid administration (time from arrival at the PACU to the first PCA press);Recovery quality scores at 24-hour preoperative, and 2, 6, 12, 24, and 48 hours postoperatively;Patients' satisfaction with the analgesic regimen at 24 and 48 hours postoperatively;NRS scores (at rest and during movement) and agitation scores during PACU stay;NRS scores at rest and during movement: baseline (24 hours preoperatively), and at 2, 6, 12, 24, and 48 hours postoperatively;Fatigue levels before surgery, at 24 and 48 hours postoperatively, and on the day of discharge;Preoperative anxiety and information scale (APAIS) score before surgery;Postoperative opioid consumption at 48 hours;	—

Measure

Time frame

Time to first postoperative opioid administration (time from arrival at the PACU to the first PCA press);Recovery quality scores at 24-hour preoperative, and 2, 6, 12, 24, and 48 hours postoperatively;Patients' satisfaction with the analgesic regimen at 24 and 48 hours postoperatively;NRS scores (at rest and during movement) and agitation scores during PACU stay;NRS scores at rest and during movement: baseline (24 hours preoperatively), and at 2, 6, 12, 24, and 48 hours postoperatively;Fatigue levels before surgery, at 24 and 48 hours postoperatively, and on the day of discharge;Preoperative anxiety and information scale (APAIS) score before surgery;Postoperative opioid consumption at 48 hours;

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Countries

China

Contacts

Public ContactCui Lingli

Beijing Friendship Hospital ,Capital Medical University

clinly@126.com+86 10 63138761

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026