cognitive impairment
Conditions
Interventions
Intervention group:Multidomain Interventions
Control group:Routine health education
Sponsors
West China Fourth Hospital, Sichuan University / West China School of Public Health
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged 60 years or older; 2. A score of >=18 on the Mini-Mental State Examination (MMSE); 3.Fewer than 6 years of formal education; 4. Meeting at least one of the following risk factors for cognitive decline: (1) History of hypertension; (2) History of diabetes mellitus; (3)Hyperlipidemia; (4)History of head trauma; (5)Physical inactivity; (6)Current smoking; (7)Excessive alcohol consumption; (8)Body Mass Index (BMI) >=28 kg/m^2; (9)A score between 5 and 9 on the 15-item Geriatric Depression Scale (GDS-15); (10)Infrequent social engagement; (11) Exposure to ambient air pollution; 5. Physically and mentally capable of participating in the intervention and complying with the study procedures; 6. Willing and able to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1.Diagnosis of dementia or other major neurodegenerative diseases; 2. Presence of any comorbidity that could impede participation in the multi-domain intervention, including psychiatric disorders, active malignancy, recent stroke, uncontrolled hypertension, among others; 3. Severe visual, auditory, or speech impairments; 4. Concurrent participation in any other interventional trial; 5. Plans to relocate within the 24-month study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychological Test Battery, NTB Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| NTB domain-specific scores;Total score and scores on each dimension of the Mini-Mental State Examination(MMSE);Obesity-related indicators;Level of physical activity;Laboratory parameters (such as blood glucose, low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), total cholesterol (TG), triglycerides (TC), etc);Blood pressure;Bone measurement;Body fat and visceral fat percentage;Physical function;Diet;Mental health;Sleep quality; | — |
Countries
China
Contacts
Public ContactJunmin Zhou
West China Fourth Hospital, Sichuan University / West China School of Public Health
Outcome results
None listed