None
Conditions
Interventions
Sevoflurane group:Participants in the Sevoflurane group will undergo anesthetic induction and maintenance with inhaled sevoflurane
Propofol group:Participants in the Propofol group will undergo anesthetic induction and maintenance with intravenous propofol.
Sponsors
Sichuan Academy of Medical Sciences-Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 70 years, inclusive, regardless of gender. 2. Body Mass Index (BMI) between 18 kg/m² and 30 kg/m², inclusive. 3. Scheduled to undergo general anesthesia with double-lumen endotracheal intubation. 4. Preoperative chest CT scan shows a pulmonary lesion with the largest diameter <= 2 cm. 5. American Society of Anesthesiologists (ASA) Physical Status classification of I or II. 6. Willingness to participate in the study and provision of written informed consent.
Exclusion criteria
Exclusion criteria: 1. Preoperative CT indicating pulmonary infection, atelectasis, and hydropneumothorax; 2. History of previous pulmonary surgery; 3. Forced expiratory volume in the first second/predicted value (FEV1%) = III); 7. History of cerebrovascular accident or cerebral infarction; 8. History of respiratory diseases (e.g., chronic obstructive pulmonary disease, bronchiectasis, pulmonary bullae, interstitial lung disease); 9. Severe hepatic dysfunction (hepatic failure or Child-Pugh class B or C); 10. Chronic renal failure (glomerular filtration rate < 30 mL/min); 11. Presence of psychiatric disorders leading to non-cooperation; 12. Participation in other clinical trials as a subject within 3 months prior to enrollment; 13. Patient refusal to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relative Concentrations of Plasma Energy Metabolites; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of postoperative complications related to anesthesia; | — |
Countries
China
Contacts
Public ContactPeng Li
Sichuan Academy of Medical Sciences-Sichuan Provincial People's Hospital
Outcome results
None listed