Ventricular premature contraction originating from the right ventricular outflow tract
Conditions
Interventions
Experimental group (PFA group):Receiving pulsed electric field ablation treatment.
Control group (RFA group):Radiofrequency ablation treatment
Sponsors
The Second Affiliated Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 75 years old (inclusive), no gender restrictions; 2. The clinical diagnosis was symptomatic premature ventricular contractions; 3. Ventricular extrasystole was monomorphic and originated from right ventricular outflow tract (left bundle branch block in chest leads and high R in inferior leads); 4. 24-hour dynamic electrocardiogram shows a count of more than 10,000 episodes of ventricular premature contractions per 24 hours; 5. The treatment effect of anti-arrhythmic drugs (AADs) is poor, or the patient cannot tolerate or is unwilling to accept the treatment with AADs;
Exclusion criteria
Exclusion criteria: 1. Previous treatment with right ventricular outflow tract catheter ablation; 2. NYHA is classified as III to IV; 3. LVEF 3 times the upper limit of normal, serum creatinine (Cr) > 2 times the upper limit of normal or undergoing dialysis treatment); 7. poorly controlled diabetes mellitus or hypertension; 8. Pregnant or lactating women, as well as those who plan to become pregnant during the course of the study; 9.Pregnant or lactating women and those planning to conceive during the study period; 10. Life expectancy < 12 months; 11. Those who are currently participating in clinical research studies for any other medications or medical devices and have not yet completed their participation; 12. Situations in which it is deemed inappropriate for an individual to participate in this research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate of ablation 90 days post-surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immediate surgical success rate;Surgical procedure duration;LVEF 90 days post-surgery;The incidence rate of major adverse events 90 days after surgery.;X-ray exposure time;Incidence of severe adverse events 90 days post-surgery;PVC load after 90 days post-surgery;Left ventricular end-diastolic diameter 90 days post-surgery.;Dissolution Time;Number of PVCs 90 days post-surgery.; | — |
Countries
China
Contacts
Public ContactFan Yougi
The Second Affiliated Hospital of Zhejiang University School of Medicine
Outcome results
None listed