Vertebrobasilar Dolichoectasia
Conditions
Interventions
Symptomatic Vertebrobasilar Dolichoectasia :None
Asymptomatic Vertebrobasilar Dolichoectasia:None
Sponsors
China Medical University Fourth Affiliated Hospital, Department of Radiology
Eligibility
Sex/Gender
All
Age
20 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Participants aged 20 to 90 , regardless of gender, who are capable of understanding and signing the informed consent form. 2. Diagnosis of Vertebrobasilar Dolichoectasia confirmed by Magnetic Resonance Angiography or Computed Tomography Angiography, defined as follows: Basilar Artery diameter greater than 4.5 mm at the mid-pons level, overall elongated length exceeding 29.5 mm, or lateral displacement greater than 10 mm from the line connecting the origin and bifurcation of the BA; or intracranial Vertebral Artery diameter greater than 4.0 mm, or length exceeding 23.5 mm. 3. Classification into symptomatic group or asymptomatic group based on clinical presentation. The symptomatic group exhibits clinical signs such as posterior circulation ischemic stroke, brainstem/cranial nerve compression symptoms, hydrocephalus, or ataxia, confirmed by a neurologist. The asymptomatic group has radiologically confirmed VBD but lacks the aforementioned clinical symptoms. 4. No prior High-Resolution Magnetic Resonance Vessel Wall Imaging examination. 5. Ability to tolerate MRI scanning, with no absolute contraindications to MRI.
Exclusion criteria
Exclusion criteria: 1. Presence of other non-atherosclerotic cerebrovascular diseases, such as arterial dissection, Moyamoya disease, vasculitis, aneurysm, vascular malformation, or central nervous system tumor. 2. Severe stenosis greater than 50 percent or occlusion in the anterior or posterior circulation, or potential cardiogenic embolic sources. 3. Systemic diseases affecting cerebral hemodynamics, such as intracranial space-occupying lesions, arteriovenous fistula, significant cerebral edema, severe anemia, or use of medications significantly affecting cerebral blood flow. 4. Incomplete imaging data, poor image quality precluding clear visualization of the vessel wall, or inability to complete the MRI scan. 5. Pregnant or lactating women, or individuals with severe cognitive impairment preventing cooperation with the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Predictive performance of symptomatic VBD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation coefficient between clinical symptoms and key imaging markers; | — |
Countries
China
Contacts
Public ContactWu Yejun
The Fourth Affiliated Hospital of China Medical University
Outcome results
None listed