The effective dose of oliceridine for postoperative analgesia in children after laparoscopic hernia repair: A dose-finding study based on the biased coin design sequential method

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500111172

Enrollment

Unknown

Registered

2025-10-27

Start date

2025-10-28

Completion date

Unknown

Last updated

2025-11-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inguinal hernia

Interventions

School-age group:Injection oliceridine

Preschool group:Injection oliceridine

Eligibility

Sex/Gender

All

Age

4 Years to 10 Years

Inclusion criteria

Inclusion criteria: 1. Aged 4-10 yr, 2. Children of both sexes, 3. Undergoing laparoscopic hernia repair surgery, 4. American Society of Anesthesiologists physical status I or II, 5. The patient and guardian voluntarily sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. The patient has a history of allergy to the test medication, 2. The patient has a history of asthma, congenital heart disease, and liver or kidney dysfunction, 3. The patient has neurological or mental disorders, 4. The patient has taken benzodiazepines and analgesics continuously or intermittently recently,

Design outcomes

Primary

Measure	Time frame
The ED90 and its 95% confidence interval of oliceridine for postoperative analgesia after laparoscopic hernia repair in children;	—

Secondary

Measure	Time frame
Emergence delirium;Exbation time;Excessive sedation;Delayed recovery;Vital signs;	—

Countries

China

Contacts

Public ContactZhang Ruidong

Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine

doctorruidong@163.com+86 189 1663 7626

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026