Precancerous lesions of gastric cancer
Conditions
Interventions
Normal control group:None
Intestinal metaplasia group:None
gastric dysplasia group:None
Sponsors
Shenzhen Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Pathologically confirmed intestinal metaplasia / low-grade intraepithelial neoplasia / high-grade intraepithelial neoplasia or gastric adenocarcinoma, and the patient has undergone radical surgery without neoadjuvant therapy. 2. Surgical or endoscopic resection that can provide a single piece of tissue >=50 mg (about the size of a soybean). 3. Age 18–65 years.
Exclusion criteria
Exclusion criteria: 1. Concomitant other malignant tumors, severe dysfunction of major organs (heart, liver, kidney, etc.), or serious hematological, neurological, or psychiatric diseases. 2. Helicobacter pylori eradication therapy within the past six months. 3. Prior gastric radiotherapy or chemotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastroscopy and pathology findings;single-cell transcriptomic atlas; | — |
Secondary
| Measure | Time frame |
|---|---|
| Organoid functional validation;predictive performance of molecular biomarkers; | — |
Countries
China
Contacts
Public ContactShaoju Guo
Shenzhen Hospital of Traditional Chinese Medicine
Outcome results
None listed