Severe acute pancreatitis
Conditions
Interventions
NM group:nafamostat mesylate
H group:Heparin pump for anticoagulation
Sponsors
Weifang People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) adults over 18 years old, (2) diagnosed with severe acute pancreatitis (SAP) according to the revised Atlanta classification (2012), meeting at least one of the following: Persistent organ failure (>48 hours), or APACHE II score >=8 or SOFA score >=4 at ICU admission, (3) requiring blood purification therapy (continuous renal replacement therapy [CRRT] or hemoperfusion) due to systemic inflammatory response, acute kidney injury, or hypercytokinemia, (4) informed consent obtained from patient or surrogate.
Exclusion criteria
Exclusion criteria: (1) known hypersensitivity or contraindication to NM or UFH, (2) severe coagulation disorders (INR >2.0), active major bleeding (such as intracranial hemorrhage, ongoing gastrointestinal bleeding) or recent uncontrolled bleeding and bleeding diseases or platelet count <30×10?/L, (3) severe hepatic failure (Child–Pugh C) , (4) History of heparin-induced thrombocytopenia (HIT), (5) pregnancy or lactation. (6) chronic kidney disease requiring dialysis before ICU admission, (7) expected survival <48 hours or refusal to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| average service life of the blood purification circuit or filter.; | — |
Secondary
| Measure | Time frame |
|---|---|
| SOFA and APACHE II changes from the baseline ;Changes in PCT, CRP, IL-6, IL-10 and TNF-a; | — |
Countries
China
Contacts
Public ContactGao Zhipeng
Weifang People's Hospital
Outcome results
None listed