Intravenous micro-dose dexmedetomidine reduces the incidence of emergence agitation in patients: a prospective, double-blind, randomized controlled single-center clinical study

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500111155

Enrollment

Unknown

Registered

2025-10-27

Start date

2025-11-01

Completion date

Unknown

Last updated

2025-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative agitation after surgery

Interventions

Experimental group:Intravenous injection of 0.2 µg/kg with a concentration of 4 µg/ml dexmedetomidine hydrochloride injection

Control group:Intravenous injection of the same volume of saline as the experimental group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Undergo ureteroscope surgery; 2. ASA I-II level, cardiac function Class I, and patients with sinus rhythm on ECG; 3. The patient or their family can provide written informed consent.

Exclusion criteria

Exclusion criteria: 1. Severe cardiovascular and cerebrovascular diseases; 2. Liver and kidney dysfunction; 3. Coagulation disorders; 4. Patients who use analgesic and sedative drugs for a long time.

Design outcomes

Primary

Measure	Time frame
Ricker Sedation-Agitation Scale during extubation;VAS score at extubation;	—

Secondary

Measure	Time frame
Mean arterial pressure;Heart rate;Blood oxygen saturation;Surgery time;Awake time;Time of catheter removal;Postoperative nausea and vomiting;Postoperative cognitive dysfunction;	—

Countries

China

Contacts

Public ContactZhiwei Wang

Guangzhou Huadu District People's Hospital

617068989@qq.com+86 151 0205 9527

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026