Gallbladder disorders
Conditions
Interventions
Experimental group(T group):Administration of Tegileridine Fumarate for postoperative analgesia
Control group(C group):Inject the same volume of normal saline
Sponsors
Jingmen People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18–65 years; 2. Laparoscopic cholecystectomy under general anesthesia; 3. No history of drug allergies; 4. Complete clinical data; 5. ASA classification: I–II (American Society of Anesthesiologists classification, indicating good physical condition); 6. Informed consent: patients voluntarily participate in the study and sign an informed consent form; 7. No serious underlying diseases: such as normal heart, lung, liver, and kidney function; 8. This study protocol has been approved by the hospital's medical ethics committee, and patients have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe systemic diseases: such as severe cardiovascular diseases, liver and kidney dysfunction, immune system disorders, etc.; 2. Pregnant or breastfeeding women: to avoid potential effects of drugs on the fetus or infant; 3. Long-term use of anti-inflammatory or analgesic drugs: such as non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, etc.; 4. Recent infection or inflammation: patients with clear infection or inflammation before surgery (e.g., acute episode of cholecystitis); 5. Mental illness or cognitive impairment: unable to cooperate with the study or report postoperative symptoms; 6. Intraoperative conversion to open surgery, with unstable vital signs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum white blood cell count;procalcitonin;C-reactive protein;interleukin-6;tumor necrosis factor a;Postoperative gastrointestinal function; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS scores at rest and during activity after the operation;15-item Quality of Recovery Scale ;The incidence of postoperative adverse reactions; | — |
Countries
China
Contacts
Public ContactZhou Xing
Jingmen People's Hospital
Outcome results
None listed