Orthopedic surgery
Conditions
Interventions
Tegileridine Fumarate Group:After surgery, patients in the Tegileridine Fumarate group receive an intravenous loading dose of 0.75 mg Tegileridine Fumarate injection, followed by PCA (patient-controll
Morphine Group:After surgery, patients in the Morphine group receive an intravenous loading dose of 0.08 mg/kg morphine, followed by PCA (patient-controlled analgesia) configured as follows: concentra
Sponsors
Ningbo Medical Center Lihuili Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–75 years, either sex; 2. Adult patients with ASA physical status classification I–III; 3. Scheduled for elective unilateral TKA, THA, or 1–2-level spinal fusion surgery; 4. Expected postoperative hospital stay >= 3 days to facilitate observation and follow-up; 5. Able to understand the study content and voluntarily sign the written informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of allergy or severe adverse reaction to opioids or study drug; 2. Severe hepatic or renal impairment (Child-Pugh class C, or creatinine clearance 3 months) or history of opioid abuse; 6. Presence of severe psychiatric disorder, psychological impairment, or cognitive dysfunction affecting compliance or cooperation; 7. Other conditions deemed unsuitable for participation in this trial by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of pain intensity at different postoperative time points;Cumulative analgesic consumption;Total and effective number of PCA presses; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first achieve adequate analgesia (VAS = 4]);Functional recovery (TKA: knee range of motion; THA: hip range of motion and gait; spinal fusion: ODI score);Early mobility (time to first ambulation, walking time, cumulative activity duration);QoR-15 score and patient satisfaction;Length of hospital stay;Cost of managing analgesia-related adverse reactions; | — |
Countries
China
Contacts
Public ContactZhou Longyuan
Ningbo Medical Center Lihuili Hospital
Outcome results
None listed