Infectious Diseases
Conditions
Interventions
Observation group:None
Sponsors
Affiliated Hospital of Jiangnan University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Male or female patients aged >= 18 years; 2.Receiving intravenous vancomycin therapy for confirmed or clinically highly suspected Gram-positive bacterial infections; 3.Continuous vancomycin treatment duration of >= 72 hours; 4.At least one vancomycin therapeutic drug monitoring (TDM) measurement during treatment, with complete dosing records and accurate blood sampling time documentation.
Exclusion criteria
Exclusion criteria: 1.Critical information in medical records is severely missing, making pharmacokinetic analysis impossible (e.g., complete lack of key covariate data such as body weight or serum creatinine; severely ambiguous or incomplete records of vancomycin administration times or blood sample collection times); 2.Currently receiving or having previously received renal replacement therapy (RRT) during the period, but with unclear documentation of treatment mode, parameter settings, and time points, making accurate representation in the model impossible; 3.Concomitant use of drugs during treatment that significantly affect vancomycin pharmacokinetics and whose impact is difficult to quantify (e.g., oral cholestyramine); 4.Medical records indicate the patient explicitly objected to the use of their medical information for scientific research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood drug concentration; | — |
Countries
China
Contacts
Public ContactJinfang Song
Affiliated Hospital of Jiangnan University
Outcome results
None listed