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The effect and mechanism of repetitive transcranial magnetic stimulation combined with functional electrical stimulation of the chest and abdomen on the clinical outcomes of severely ill patients with mechanical ventilation

The effect and mechanism of repetitive transcranial magnetic stimulation combined with functional electrical stimulation of the chest and abdomen on the clinical outcomes of severely ill patients with mechanical ventilation

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500111143
Enrollment
Unknown
Registered
2025-10-27
Start date
2025-01-18
Completion date
Unknown
Last updated
2025-11-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurocritical care unit

Interventions

Control Group B (Thoracic and abdominal FES treatment):Thoracic and abdominal FES treatment
Control Group A (rTMS treatment):rTMS
Experimental group(rTMS treatment & Thoracic and abdominal FES treatment):rTMS treatment & Thoracic and abdominal FES treatment

Sponsors

Zhejiang Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. NCU patients: TBI, SAH, intracranial hemorrhage (ICH), ischemic stroke, central nervous system infection (brain abscess, cerebral ventriculitis, meningitis, encephalitis or brain tumor), etc. 2. Age>= 18 years old; 3.GCS =24 hours and attempting weaning (i.e., accepting weaning test); 4.No serious complications, such as cardiocerebral and renal insufficiency, deep vein thrombosis, etc. 5.Intact skin; 6.Family members sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Age 35 kg/m^2 and pregnancy]; 3.Combined with myasthenia gravis or phrenic nerve palsy; 4.History of severe heart disease, liver cirrhosis, renal failure, severe systemic diseases and malignant diseases; 5.History of lung, chest and abdominal diseases; 6.Refusal to sign informed consent.

Design outcomes

Primary

MeasureTime frame
Duration of mechanical ventilation;Length of stay in the ICU;QOL-MV Score;

Secondary

MeasureTime frame
The amplitude and latency of motor evoked potentialsCMCT;Indicators reflecting the oxygenation and blood perfusion of the tissue muscles:StO2THI;Diaphragm index:TFdiTFabd;TIE;?IAP;P0.1;

Countries

China

Contacts

Public ContactYunlan Dai

Zhejiang Provincial People's Hospital

dyl6975@163.com+86 571 87666666

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026