Acute Retinal Necrosis Syndrome
Conditions
Interventions
AI-Assisted Diagnosis and Treatment Group:Diagnostic stage: Input the patients clinical symptoms, fundus examination results, etiological detection data, etc. into the "Acute Retinal Necrosis Syndrome
Sponsors
Shanxi Eye Hospital
Eligibility
Sex/Gender
All
Age
12 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Jointly diagnosed by =2 fundus disease specialists with associate chief physician title, meeting internationally recognized ARN diagnostic criteria (referring to Takase H criteria 2015 and Uveitis Working Group criteria 2021), specifically satisfying at least 2 of the 3 core indicators: (1) peripheral retinal necrosis lesions, (2) occlusive retinal arteritis, (3) vitreous opacity, accompanied by positive HSV/VZV detection in intraocular fluid PCR or characteristic disease progression manifestations;? 2. Visited Shanxi Eye Hospital with baseline data including 23 core indicators (demographic characteristics, etiological typing, retinal vascular occlusion range, treatment plan, etc.), with key data missing rate <=5%;? 3. Informed consent obtained from patients or legal guardians, able to cooperate with = 3 months of follow-up to collect prognostic data such as retinal detachment and visual acuity changes;? 4. No restrictions on age or gender, including patients with monocular/binocular involvement, covering different disease severities (mild/moderate/severe) and etiological types (VZV/HSV infection) to ensure sample representativeness.
Exclusion criteria
Exclusion criteria: 1. Not meeting ARN diagnostic criteria, or diagnosed with confused diseases (e.g., CMV retinitis, toxoplasmic retinochoroiditis, proliferative diabetic retinopathy, etc.);? 2. Missing rate of core indicators (etiological results, treatment plan, visual acuity monitoring, etc.) >5%, which cannot be supplemented by clinical records;? 3. Complicated with severe heart/liver/kidney failure, advanced malignancy, etc., with expected survival < 3 months, or unable to cooperate with follow-up due to mental disorders;? 4. Previous ocular surgeries (except uncomplicated cataract surgery with good recovery) such as corneal transplantation and glaucoma filtration surgery, which may affect diagnosis, treatment and prognostic evaluation;? 5. Refusing to provide clinical data for model construction, or disagreeing to participate in follow-up and verification procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of retinal detachment;Best Corrected Visual Acuity;Involvement of the second eye;Baseline characteristics (e.g., age, gender, affected eye); | — |
Secondary
| Measure | Time frame |
|---|---|
| Vitreous inflammation grading;Time from symptom onset to antiviral treatment;Comorbidity status; | — |
Countries
China
Contacts
Public ContactZhang Yu
Shanxi Eye Hospital
Outcome results
None listed