None
Conditions
Interventions
Observation group:none
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
3 Years to 80 Years
Inclusion criteria
Inclusion criteria: Health Group 1. Age>= 3 years; either sex. 2. No history of severe cardiac, pulmonary or other systemic disorders; in particular, no previous respiratory disease or thoracic surgery. 3. No respiratory infection within the past 4 weeks; lifetime smoking = 40 years; either sex. 2. Suspected COPD: COPD-SQ >=16 without persistent airflow limitation. Confirmed COPD: post-bronchodilator FEV1/FVC = 3 years; either sex. 2. Suspected asthma: chronic respiratory symptoms (wheeze, cough, chest tightness or dyspnoea) without demonstrable variable airflow limitation. Confirmed asthma: evidence of variable airflow limitation—e.g. positive bronchodilator reversibility, positive bronchial challenge, or mean daily diurnal PEF variability > 10 % over at least 7 consecutive days. 3. Signed informed consent. Confirmed Bronchiectasis Group 1. Age >= 3 years; either sex. 2. Clinical picture compatible with bronchiectasis (chronic productive cough, haemoptysis and/or recurrent respiratory infections) plus CT confirmation. 3. No concomitant respiratory disease. 4. Signed informed consent. Confirmed Interstitial Lung Disease (ILD) Group 1. Age >= 3 years; either sex. 2. Fibrotic ILD on HRCT: reticulation with traction bronchiectasis or honey-combing affecting > 10 % of lung volume; or histological evidence of interstitial changes. 3. No other active respiratory disorder. 4. Signed informed consent. Confirmed Upper-Airway Obstruction Group 1. Age >= 3 years; either sex. 2. Documented cause of large-airway narrowing: inflammation, injury, intubation/tracheostomy, burns, foreign-body aspiration, tracheal tumour, etc. 3. Predominant symptoms of dyspnoea, worsened by exertion and sometimes by posture. 4. Flow–volume curve showing characteristic plateau of inspiratory and/or expiratory flow. 5. Objective evidence of stenosis: – CT thorax or 3-D reconstruction demonstrating upper-airway narrowing; OR – Laryngo-/bronchoscopy showing wall thickening, luminal narrowing, intraluminal nodules/neoplasm, mucosal hyperaemia or collapsed cartilage. 6. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Contraindications for impulse oscillation system pulmonary function testing: Severe dyspnea rendering the test intolerable; acute exacerbation of respiratory tract infection; uncontrolled epilepsy; oral or facial diseases/malformations preventing proper bite-block placement; tympanic membrane perforation; requiring continuous oxygen therapy; indwelling nasogastric tube; tracheostomy tube unable to be occluded; currently undergoing mechanical ventilation that cannot be temporarily discontinued. 2.Contraindications for forced ventilatory function testing: recent severe cardiovascular disease, epileptic seizures, uncontrolled hypertension, aortic aneurysm, severe hyperthyroidism, heart rate >120 beats/min, tympanic membrane perforation, other infectious respiratory diseases; 3. Other respiratory diseases affecting pulmonary function results, such as lung cancer, pneumonia, active tuberculosis, pulmonary embolism, etc.; recent surgical history affecting pulmonary function results, including thoracotomy, pleural effusion surgery, etc.; 4.Poor compliance with baseline pulmonary function testing, failing to meet quality control requirements; 5.Pregnant women; 6.Participants deemed by the investigator unlikely to adhere to study protocols and restrictions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic performance; | — |
Countries
China
Contacts
Public ContactYi Gao
The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed