Female Thyroid Surgery
Conditions
Interventions
Group E:Administer esomeprazole 40 mg intravenously over 3 minutes 30 minutes prior to induction of anesthesia (dissolve one vial of esomeprazole 40 mg lyophilized powder in 5 mL of normal saline).
Group C:Administer 5 mL of normal saline via intravenous injection over 3 minutes 30 minutes prior to anesthesia induction.
Sponsors
Anqing Municipal Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–65 years; 2. BMI 18–30 kg/m^2; 3.ASA I–III; 4.Female patients scheduled for elective thyroidectomy under general anesthesia; 5.History of motion sickness or PONV; 6.No gastrointestinal disease; no prior gastrointestinal surgery except simple cholecystectomy; 7.Normal communication ability; 8. Voluntary participation and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Allergy to esomeprazole; 2.Administration of antiemetics or analgesics within 24 hours prior to surgery; 3.Use of H2 receptor antagonists or PPIs; 4.Use of medications interacting with esomeprazole (e.g., phenytoin, diazepam, ketoconazole, itraconazole, warfarin/vitamin K antagonists, clopidogrel); 5.Use of antipsychotic drugs or corticosteroids; 6.History of heart failure or arrhythmia; uncontrolled hypertension; diabetes with poor glycemic control; hepatic or renal impairment; gastrointestinal motility disorders; vestibular disorders; 7. Pregnant or lactating women; 8.Unable to understand the Quality of Recovery-15 (QoR-15)/Visual Analogue Scale (VAS)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Preoperative and 24-Hour Postoperative Quality of Recovery-15 (QoR-15) Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of PONV at 1 hour, 6 hours, and 24 hours postoperatively;Postoperative pain VAS scores at 1 hour, 6 hours, and 24 hours;Use of rescue antiemetics and rescue analgesics;Postoperative Ramsay Sedation Scale in the PACU and PACU Stay Duration;First passage of gas/bowel movement; Length of hospital stay First passage of gas/bowel movement; Length of hospital stay;Severity of PONV; | — |
Countries
China
Contacts
Public ContactWu Xiongzhi
Anqing Municipal Hospital
Outcome results
None listed