Lumbar Spondylosis
Conditions
Interventions
Esketamine group (Group E): Continuous infusion of esketamine before induction, with a loading dose of 0.3 mg/kg//h, completed within 10 minutes, followed by maintenance at a rate of 0.25 mg/kg/h unti
Control group (Group C):Intravenous pump infusion of an equal amount of saline (infusion schedule same as the esketamine group).
Sponsors
The 904th Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1 Age 18-80 years, ASA classification I-III; 2 Planned elective posterior lumbar fusion of 1-3 segments under general anesthesia; 3 Patients willing to participate in the clinical trial and sign the informed consent form; 4 Expected surgery duration of 2-6 hours.
Exclusion criteria
Exclusion criteria: 1 Allergy to drugs involved in this study; 2 Known gastrointestinal motility disorders; 3 History of abdominal surgery in the past three months; 4 Abuse of narcotic sedatives or analgesics; 5 Severe cardiovascular, pulmonary, hepatic, renal, or gastrointestinal diseases; 6 Patients with mental disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| First postoperative flatus time; | — |
Secondary
| Measure | Time frame |
|---|---|
| I-FEED Score;I-FABP;IL-6;Incidence of PONV and the use of antiemetic drugs;Rest/Activity VAS Pain Score;Total intraoperative and postoperative opioid consumption;Average blood pressure and heart rate at the scheduled time points;Number of days hospitalized; | — |
Countries
China
Contacts
Public ContactXingzhi Liao
No. 101, Xingyuan North Road, Liangxi District, Wuxi City, Jiangsu Province
Outcome results
None listed