Super-refractory Status Epilepticus
Conditions
Interventions
Experimental:The experimental arm is defined by the addition of the Ketogenic Diet to standard medical therapy
Active Comparator: standard medical therapy
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
14 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. patients diagnosed with super-refractory sustained status epilepticus (SRSE) whose initial antiepileptic sustained status epilepticus (SE) treatment consisted of intravenous benzodiazepines and an antiepileptic medications (ASMs, such as valproate, levetiracetam, or phenobarbital) as well as anaesthetics (e.g., propofol) for 24 hours of SE that did not terminate, or who relapsed after reduction of anaesthetics; 2. be between 14 and 80 years of age and of either sex; and 3. the patient's legal guardian has signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1. fatty acid transport or oxidation disorders, pyruvate carboxylase deficiency and porphyrias; 2. intolerance of enteral nutrition, including intestinal obstruction; 3. use of propofol within 24 hours; 4. haemodynamic or cardiorespiratory instability (systolic blood pressure 5 times the upper limit of normal, and total bilirubin > 10 mg/dl); 6. pancreatitis; 7. pregnancy; 8. metabolic instability (blood glucose 160 mmol/L); 9. Combined septicaemia; 10. Combined with uremia; 11. SE due to hypoxic-ischemic brain injury.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| KD Improvement in prognosis;Feasibility of the KD diet; | — |
Primary
| Measure | Time frame |
|---|---|
| Efficacy in controlling SRSE; | — |
Countries
China
Contacts
Public ContactWeibi Chen
Xuanwu Hospital Capital Medical University
Outcome results
None listed