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A prospective, observational study on the efficacy and safety of Iparomlimab and Tuvonralimab Injection in the treatment of advanced malignant solid tumors after failure of standard therapy

A prospective, observational study on the efficacy and safety of Iparomlimab and Tuvonralimab Injection in the treatment of advanced malignant solid tumors after failure of standard therapy

Status
Active, not recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500111041
Enrollment
Unknown
Registered
2025-10-24
Start date
2025-11-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malignant solid tumors

Interventions

Observation group:None

Sponsors

The First Hospital of Nanping City, Fujian Province
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.The study included participants whose age was 18 years or older at the time of enrollment, with no restrictions on gender. 2.Patients who have been clinically diagnosed with malignant solid tumors and have failed standard treatment, including but not limited to lung cancer, liver cancer, gastric cancer, colorectal cancer, esophageal cancer, breast cancer, cervical cancer, ovarian cancer, endometrial cancer, nasopharyngeal cancer, biliary tract cancer, etc. 3.The plan is to administer Iparomlimab and Tuvonralimab injection for treatment after the patients are enrolled. 4.The patient fully understood this study and voluntarily participated, providing a written informed consent form. Data collection can only be carried out after obtaining the written informed consent form.

Exclusion criteria

Exclusion criteria: 1.Patients with brain metastases who have cognitive impairments or those with other neurological or psychiatric disorders; 2.Those who are known to be allergic to the studied drug or its similar preparations, or to other biological products, or who are contraindicated or advised to use with caution. 3.Other researchers believe that certain circumstances are not suitable for participation in this study.

Design outcomes

Primary

MeasureTime frame
Health-related quality of life;

Secondary

MeasureTime frame
One-year/Two-year Overall Survival Rate;Duration of relief;Overall survival time;Disease control rate;Progression-free survival time;One-year / Two-year PFS rate;Treatment-related adverse event;

Countries

China

Contacts

Public ContactYing Zhong

The First Hospital of Nanping City, Fujian Province

847560684@qq.com+86 599 8605951

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026